The  DRCM  technology is a controlled  release system designed  to  deliver drug  content  at  a   constant  rate, independent of  Gastric cycles and Gastro-intestinal pH. The  Diffusion  Rate Controlling   Membrance (DRCM) technology is employed for acidic & neutral compounds while for basic compounds this is combined with a pH activated disintegrated mechanism.

Using  the  novel  state-of-the-art  Diffusion  Rate Controlling   Membrance   Technology   (DRCM),  the  Controlled   Release  products  are  manufactured. This consists of   pellets   programmed   to deliver  the  drug steadily   over    24    hours,   thus   ensuring     desired therapeutic effect with minimum side effects.

The  DRCM   systems   differs  from  other  forms   of Sustained Release Systems. It consists of :

i) Multiple Unit Dosage Forms (MUDFs) as compared to  the  single UNIT  dosage  form  of the  SR  systems (Tablets)
ii)The DRCM  systems  is  independent of the Stomach Emptying and G. I. Tract Transit Time.
iii)It  is  autonomous  of  the  external  environment  into which the active agent is released & it is independent of the pH of the environment in which it is realeased.

Diffusion    Rate   Controlling   Membrance    (DRCM) Technology  is employed in designing pellet formulations of  all acidic and  most   neutral compounds. Release of such  compounds in the stomach  and the upper part of the  small   intestine   can  be  controlled  by  a  suitable  combination  of  coating  substances used as a dialysing external membrance.  In  case of acidic compounds the rate  of release  in the  stomach  (where irritation could take place) will be minimised to almost NIL. However, by   moving   pellets   out  of    the  stomach   into   pH environment  of  6 or more(in small  intestine)  diffusion process  will take place and drug will release at the rate it was designed for.